Functional Interferon System Is Required for Clearance of Lassa Virus
- 15 March 2012
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 86 (6) , 3389-3392
- https://doi.org/10.1128/jvi.06284-11
Abstract
Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.Keywords
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