The Effect of Free Radicals Induced by Paraquat and Copper on theIn VitroDevelopment ofPlasmodium falciparum
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 12 (1) , 137-146
- https://doi.org/10.3109/10715769109145778
Abstract
The role of transition metals in paraquat toxicity was studied in cultures of Plasmodium falciparum. We showed that addition of copper led to an enhancement of the plasmodium killing, whereas addition of chelating agents. such as desferrioxamine and diethylenetriamine pentaacetic acid markedly reduced the toxic effects. Parsitized G6PD deficient erythrocytes were more sensitive than parasitized normal eryth-rocytes to copper and to the combination of copper and paraquat.Keywords
This publication has 25 references indexed in Scilit:
- Some roles of free radicals in malariaFree Radical Biology & Medicine, 1989
- Transition Metals Potentiate Paraquat ToxicityFree Radical Research Communications, 1985
- Roles of Copper and ${\rm O}_{2}^{\overline{\cdot}}$ in the Radiation-Induced Inactivation of T7 BacteriophageRadiation Research, 1984
- Plasmodium falciparum: Thiol status and growth in normal and glucose-6-phosphate dehydrogenase deficient human erythrocytesExperimental Parasitology, 1984
- On the cytotoxicity of vitamin C and metal ionsEuropean Journal of Biochemistry, 1983
- A RADICAL INTERPRETATION OF IMMUNITY TO MALARIA PARASITESThe Lancet, 1982
- Plasmodium falciparum: In vitro induction of resistance to aminopterinExperimental Parasitology, 1981
- Low glucose-6-phosphate dehydrogenase (G-6-PD) activity in red blood cells and susceptibility to copper-induced oxidative damageEnvironmental Research, 1980
- Human Malaria Parasites in Continuous CultureScience, 1976
- The mode of action of the bipyridylium herbicides, paraquat and diquatEndeavour, 1971