Response of Cultured Normal Human Mammary Epithelial Cells to X Rays

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Abstract
The effect of X rays on the reproductive death of cultured normal human mammary epithelial cells was examined. Techniques were developed for isolating and culturing normal human mammary epithelial cells which provide sufficient cells at 2nd passage for radiation studies, and an efficient clonogenic assay suitable for measuring radiation survival curves. Evidently, the survival curves for epithelial cells from normal breast tissue were exponential and had Do [dose required to reduce survival to O%] values of about 109-148 rad for 225 kVp X rays. No consistent change in cell radiosensitivity with the age of donor was observed, and no sublethal damage repair in these cells could be detected with the split-dose technique.

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