Does the Third Pancreatic Hormone (APP) Play a Trophic Role in the Growth of the Embryonic Chick Proventriculus?

Abstract
Avian pancreatic polypeptide (APP) is a recently discovered pancreatic peptide with hormone-like characteristics which acts as a gastric (proventricular) secretagogue in chickens. When injected into 12-14 day old fertile eggs, APP caused a marked increase in proventricular protein/DNA ratio within 2 days, and caused incorporation of labeled [14C]Leu into proventricular, but not into liver, protein unless very high doses were employed. APP may be an anabolic and secretogogic regulator of the developing avian gut.

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