High-Incidence of C9 Deficiency throughout Japan: There Are No Significant Differences in Incidence among Eight Areas of Japan
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 90 (4) , 400-404
- https://doi.org/10.1159/000235061
Abstract
From 92,686 sera sent from hospitals throughout Japan to the Special Reference Laboratories, for CH50 assay, we were able to classify 80 patients as C9-deficient using a sensitive screening test, as well as hemolytic and immunochemical C9 assays. The incidence of C9 deficiency was determined to be 0.086%, and there were no distinct differences among the eight areas of Japan tested. Serum CH50 levels of these C9-deficient patients varied widely (9.4–63.8 U/ml), and exhibited a higher value (average: 34.1 U/ml) than that of healthy C9-deficient individuals, probably due to elevated C3, C4, and C5 levels. These patients suffered from a variety of autoimmune, renal, and infectious diseases, which, however, are thought to be only incidentally associated with C9 deficiency.Keywords
This publication has 1 reference indexed in Scilit:
- A high incidence of C9 deficiency among healthy blood donors in Osaka, JapanInternational Immunology, 1989