The tautomeric conversion of p-hydroxyphenylpyruvic acid

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Abstract
In aqueous soln., the conversion of p-hydroxyphenylpyruvic acid from the enolic to the ketonic form was greatly accelerated in alkaline soln. In guinea-pig urine, the conversion to the ketonic form took place more rapidly than in water at all values of pH investigated. Probably the conversion proceeds in guinea-pig tissue at a rate similar to that in urine. In both cases, approx. 99% of the p-hydroxyphenylpyrmdc acid existed in the ketonic form. The detn. of p-hydroxy-phenylpyruvic acid in guinea-pig urine by the Briggs reaction or by indophenol titration does not yield satisfactory results, but the Penrose and Quastel reaction is reliable.