STIMULATION BY LUTEINIZING HORMONE OF ORNITHINE DECARBOXYLASE IN RAT OVARY: PREFERENTIAL RESPONSE BY FOLLICULAR TISSUE

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Abstract
Department of Biodynamics, Weizmann Institute of Science, Rehovot, Israel (Received 4 June 1974) Luteinizing hormone (LH) stimulates ovarian ornithine decarboxylase (ODC), the first enzyme in the pathway of polyamine synthesis, when injected into mature (Kobayashi, Kupelian & Maudsley, 1971; Jänne & Williams-Ashman, 1971) or immature rats (Kaye, Icekson, Lamprecht, Gruss, Tsafriri & Lindner, 1973). Kobayashi et al. (1971) observed a rise in ovarian ODC activity on the afternoon of prooestrus, which may be related to the ovulatory process (Kobayashi et al. 1971) and/ or the early stages of corpus luteum formation (Williams-Ashman, Jänne, Coppoc, Geroch & Schenone, 1972). We show here that ovarian ODC activity is stimulated by LH preferentially in the Graafian follicle. Groups of three to five Wistar-derived female rats (approximately 100 days old) selected after at least two successive regular 4-day oestrous cycles, were used for surgical isolation of Graafian follicles and corpora lutea. Only corpora lutea

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