Expression of MHC Antigens by Mouse Thymic Dendritic Cells
Open Access
- 1 June 1979
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 122 (6) , 2508-2515
- https://doi.org/10.4049/jimmunol.122.6.2508
Abstract
Thymic epithelial cells express MHC antigens in several different patterns. I-A is present throughout the thymic cortex on dendritic cells. The remainder of the I region and H-2K/D are expressed on dendritic cells apparently only variably in the cortex (at least in some haplotypes). All MHC antigens tested are present in the medulla on epithelial cells; expression on medullary lymphocytes cannot be evaluated. Monoclonal anti-MHC antibodies confirm these results. The significance of these findings to T cell maturation is discussed.Keywords
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