The ageing mitochondrial genome
Open Access
- 2 October 2007
- journal article
- review article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 35 (22) , 7399-7405
- https://doi.org/10.1093/nar/gkm635
Abstract
The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding the mechanisms involved in the ageing process. One plausible mechanism for ageing is accumulation of mutations in the mitochondrial genome. In this review, we discuss some of the most convincing data surrounding age-related mtDNA mutations and the evidence that these mutations contribute to the ageing process.Keywords
This publication has 57 references indexed in Scilit:
- Clonally expanded mtDNA point mutations are abundant in individual cells of human tissuesProceedings of the National Academy of Sciences, 2002
- Late-Onset Corticohippocampal Neurodepletion Attributable to Catastrophic Failure of Oxidative Phosphorylation in MILON MiceJournal of Neuroscience, 2001
- Increasedin vivoapoptosis in cells lacking mitochondrial DNA gene expressionProceedings of the National Academy of Sciences, 2001
- Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replicationProceedings of the National Academy of Sciences, 2001
- Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with ageNeurobiology of Aging, 2001
- Random Intracellular Drift Explains the Clonal Expansion of Mitochondrial DNA Mutations with AgeAmerican Journal of Human Genetics, 2001
- Point Mutations of the mtDNA Control Region in Normal and Neurodegenerative Human BrainsAmerican Journal of Human Genetics, 2001
- Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopeniaThe FASEB Journal, 2001
- Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for ReplicationScience, 1999
- Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscleAnnals of Neurology, 1998