Pharmacology of the Aorta

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Abstract
This brief review discusses some aspects of drug action on the spirally cut mammalian aorta. Drugs interact with one or more of five major areas: nerves innervating the tissue; drug receptors presumably located on the membrane; one of the steps in the sequence of events connecting the receptor with the contractile apparatus; the membrane itself, and the contractile proteins. Aortic responses to drugs are influenced by various factors including species variation, hormones, and aging. Ca++ mobilization appears to be the central step in the overall control of vascular smooth muscle responsiveness.

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