Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

Open Access
Publisher Website
Google Scholar
Abstract
TUMOUR metastasis is the principal cause of death for cancer patients1. We have identified the nm23 gene, for which RNA levels are reduced in tumour cells of high metastatic potential2–5. In this report we identify the cytoplasmic and nuclear Nm23 protein, and show that it also is differentially expressed in metastatic tumour cells. We also find that the human Nm23 protein has sequence homology over the entire translated region with a recently described developmentally regulated protein in Drosophila, encoded by the abnormal wing discs (awd) 6–8 gene. Mutations in awd cause abnormal tissue morphology and necrosis and widespread aberrant differentiation in Drosophila6, analogous to changes in malignant progression. The metastatic state may therefore be determined by the loss of genes such as nm23/ awd which normally regulate development.