CORRELATION OF ESTROGEN AND PROGESTERONE RECEPTORS WITH HISTOLOGIC DIFFERENTIATION IN ENDOMETRIAL ADENOCARCINOMA
- 1 January 1979
- journal article
- research article
- Vol. 96 (1) , 171-183
Abstract
Endometrial carcinomas from 58 patients were graded histologically and the histologic grade was compared with the estrogen and progesterone receptor content of the tumor tissues. Receptor content was determined by multiple concentration saturation analysis and sucrose density gradient analysis. A positive correlation was found between the presence of estrogen and progesterone receptors and the degree of tumor differentiation. The majority (85%) of well-differentiated lesions contained significant amounts of both steroid receptor proteins. Only 13% of the poorly differentiated lesions were characterized by the presence of detectable levels of estrogen and progesterone receptor proteins. The relationship of receptor content and degree of differentiation to prognosis and potential for response to hormonal therapy was discussed.Keywords
This publication has 27 references indexed in Scilit:
- ESTROGEN AND PROGESTERONE RECEPTORS IN THE FEMALE GENITAL TRACT OF HUMANS AND MONKEYS*Annals of the New York Academy of Sciences, 1977
- OESTROGEN EXCRETION AND OVARIAN PATHOLOGY IN POSTMENOPAUSAL WOMEN WITH ATYPICAL HYPERPLASIA, ADENOCARCINOMA AND MIXED ADENOSQUAMOUS CARCINOMA OF THE ENDOMETRIUMBJOG: An International Journal of Obstetrics and Gynaecology, 1977
- Use of the direct linear plot to estimate binding constants for protein-ligand interactionsBiochemical and Biophysical Research Communications, 1976
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- Progesterone-binding protein in human myometrium. Binding site concentration in relation to endogenous progesterone and estradiol-17β levelsThe Journal of Steroid Biochemistry and Molecular Biology, 1975
- Specific progesterone receptors in human breast cancerSteroids, 1975
- Characterization and Comparison of Receptors for 17?-Estradiol and Progesterone in Human Proliferative Endometrium and Endometrial CarcinomaEndocrinology, 1975
- Improved computer program data for the resolution and fractionation of macromolecules by isokinetic sucrose density gradient sedimentationAnalytical Biochemistry, 1974
- The cytoplasmic progesterone receptor of human endometrium during the menstrual cycleJournal of Steroid Biochemistry, 1974
- In vitro effects of progestins on DNA synthesis in metastatic endometrial carcinomaGynecologic Oncology, 1974