SECRETION OF NICKEL IN RABBIT SALIVA

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 9  (6) , 479-486
Abstract
Secretion of Ni into unstimulated and stimulated saliva of rabbits was studied after a single i.p. injection of NiCl2 labeled with 63Ni. Maximum 63Ni in unstimulated saliva was obtained in specimens collected 1 h after maximum serum-63Ni was reached and 2 h after the Ni administration. Compared to serum-63Ni, the secretion of isotope into saliva was low whether or not stimulation was carried out. After 24 h, only traces of radioactivity were left in saliva. Salivary-63Ni (40-60%) was ultrafiltrable. Most Ni associated with salivary proteins was weakly bound. Two acidic protein fractions obtained by gel filtration of saliva seemed to bind Ni firmly at neutral pH. No binding of Ni to salivary proteins was observed after the in vitro addition of normal saliva to 63NiCl2.