Expression of the c-myb and c-myc genes is regulated independently in differentiating mouse erythroleukemia cells by common processes of premature transcription arrest and increased mRNA turnover.
Open Access
- 1 September 1988
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 8 (9) , 3938-3942
- https://doi.org/10.1128/mcb.8.9.3938
Abstract
The mechanisms that modulate c-myb mRNA levels in mouse erythroleukemia cells induced toward erythroid differentiation were compared with those that act on c-myc. Both genes exhibited regulation at the levels of premature transcription arrest and RNA turnover. However, these common processes allowed temporally distinct control of gene expression.This publication has 27 references indexed in Scilit:
- Differential Expression of c- myb mRNA in Murine B Lymphomas by a Block to Transcription ElongationScience, 1987
- Changes in gene expression associated with induced differentiation of erythroleukemia: protooncogenes, globin genes, and cell division.Proceedings of the National Academy of Sciences, 1986
- Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiationNature, 1986
- Expression of a transfected human c-myconcogene inhibits differentiation of a mouse erythroleukaemia cell lineNature, 1986
- A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cellsNature, 1986
- Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitmentNature, 1986
- Transcriptional and post-transcriptional regulation of c-mye expression during the differentiation of murine erythroleukemia Friend cellsNucleic Acids Research, 1986
- Regulated expression of the c‐myb and c‐myc oncogenes during erythrdid differentiationJournal of Cellular Biochemistry, 1986
- Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemiaNature, 1984
- Differential expression of the amv gene in human hematopoietic cells.Proceedings of the National Academy of Sciences, 1982