Studies on the relationship between the catecholamine distribution in the atrium and the specific granules present in atrial muscle cells: 1. Isolation of a purified specific granule subfraction
- 1 May 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 7 (3) , 351-363
- https://doi.org/10.1093/cvr/7.3.351
Abstract
Electron microscopy of mammalian atrial muscle cells reveals a population of specific granules suggesting that the atrial muscle cells may have a secretory function. As a preliminary step towards the investigation of the function of the specific granules, a procedure was designed to isolate these particles by differential and density gradient centrifugation of rat atrial homogenates. The specific granule preparation obtained showed a considerable degree of purification with respect to marker enzymes. The isolated granules retained their in situ fine structure and staining properties.Keywords
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