ANTAGONISM BY NALOXONE OF MORPHINE-INDUCED SINGLE-DOSE DEPENDENCE AND ANTINOCICEPTION IN MICE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (4) , 689-696
Abstract
Single-dose physical dependence on morphine, as indicated by the mouse withdrawal jumping test, was reduced in a dose-related fashion by co-administration of naloxone. In the same dose range, naloxone also antagonized the antinociceptive effect of morphine in the mouse writhing test. Dose-response data revealed essentially the same ED50 for naloxone in both tests. Naloxone apparently blocks the development of morphine-induced single-dose physical dependence in mice; it does so as effectively as it blocks morphine-induced inhibition of writhing.

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