Preparation and evaluation of 2-substituted anthraquinones based on the anthracyclines
- 1 April 1982
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 25 (4) , 369-373
- https://doi.org/10.1021/jm00346a008
Abstract
Anthraquinones substituted at the 2 position with a basic side chain were prepared, and their binding to DNA was evaluated. All compounds showed an intercalative mode of binding to DNA; 1,4-dihydroxy derivatives bound more strongly than 1-hydroxy or nonhydroxylated compounds. Greatest DNA-binding activity was found where there were 5 atoms between the anthraquinone ring and the basic nitrogen. [The compounds prepared were tested for activity against P-388 leukemia in mice.].This publication has 6 references indexed in Scilit:
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