Synthesis of dopastin, a dopamine β-hydroxylase inhibitor of microbial origin
- 1 January 1973
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 4,p. 147-148
- https://doi.org/10.1039/c39730000147
Abstract
Dopastin has been synthesised from L-valinol by an 8-step procedure, in which the key stage involves oxaziran formation followed by hydrolysis with Dowex 50W, with retention of the absolute configuration of the starting material in the final product.Keywords
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