RNA-SYNTHESES IN BHK21 CELLS INFECTED BY RABIES VIRUS

  • 1 January 1977
    • journal article
    • research article
    • Vol. A128  (4) , 477-488
Abstract
In [baby hamster kidney] BHK21 cells infected by rabies virus, viral RNA syntheses are detectable from the first 4 h until at least 20 h after the adsorption period with maximum synthesis between 8-12 h. Cellular RNA syntheses are not inhibited by the virus. Viral RNA syntheses are 10 times less than syntheses induced in infected cells by VSV [vesicular stomatitis virus]. At least 3 molecules are synthesized: short (+) molecules sedimenting between 8-25 S, and possibly at 30 S; partially or totally double-stranded structures sedimenting between 25-35 S; and (+) and (-) molecules of the entire genome length. The relative amount of these 3 molecules does not seem to vary during the viral cycle.

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