The use of misoprostol prior to hysteroscopy in postmenopausal women
Open Access
- 1 July 2001
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 16 (7) , 1486-1488
- https://doi.org/10.1093/humrep/16.7.1486
Abstract
BACKGROUND: This study examined whether oral misoprostol exerted a cervical priming effect in postmenopausal women prior to hysteroscopy. METHOD: Thirty-seven patients were randomized to receive either oral misoprostol (400 μg) or placebo (vitamin B6) 12 h prior to hysteroscopy. The resistance of the cervix to dilatation was objectively assessed by a cervical tonometer. RESULTS: The mean baseline cervical dilatation (4.2 mm in misoprostol group versus 4.4 mm in placebo group) was similar between the two groups. The mean cumulative force measured (27.7 N in misoprostol group versus 21.8 N in placebo group) was also comparable. None of the patients suffered from any significant side-effects. CONCLUSIONS: These data showed that there were no significant benefits from giving misoprostol pre-operatively in postmenopausal women, and it was concluded that oral misoprostol had no significant cervical priming effect in postmenopausal women.Keywords
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