PRELIMINARY OBSERVATIONS ON THE TREATMENT OF POSTIRRADIATION HEMATOPOIETIC DEPRESSION IN MAN BY THE INFUSION OF STORED AUTOGENOUS BONE MARROW

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Abstract
Two patients with metastatic malignancies had 400-1700 million nucleated bone marrow cells collected and stored by freezing according to the Polge method on 3 occasions. The patients then received 3 separate courses of intensive radiotherapy to the entire torso, resulting in severe hypoplasia of the bone marrow and depression of the peripheral blood counts. Intravenous re-infusion of the diluted marrow was followed by rapid repopulation of the marrow within 2-4 weeks. The experience in several less severely depressed control patients who did not receive autogenous bone marrow infusion indicates persistent marrow hypoplasia for several months following irradiation. The results reported here, and further experience in 2 cases, indicate that infusion of autogenous stored bone marrow is a safe procedure, inherently free of the risk of immune reaction or foreign tissue rejection. It appears probable that the hematopoietic recovery noted was due to the repopulation of the patients bone marrow by the infused cells.

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