Conformationally restricted P1-P1' transition state analogues. Synthesis of 1(R), 3(R) [1(S), 2(S)] and 1(S), 3(S) [1(S), 2(S)] 3-[3-cyclohexyl-2-[(BOC)amino]-1-hydroxypropyl]-2,2-dimethylcyclo propane carboxylic acids
- 31 December 1990
- journal article
- Published by Elsevier in Tetrahedron Letters
- Vol. 31 (7) , 961-964
- https://doi.org/10.1016/s0040-4039(00)94403-4
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potencyJournal of Medicinal Chemistry, 1988
- Synthesis and biological activity of some transition-state inhibitors of human reninJournal of Medicinal Chemistry, 1988
- Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacementJournal of Medicinal Chemistry, 1987
- Renin inhibitors based on novel dipeptide analogs. Incorporation of the dehydrohydroxyethylene isostere at the scissile bondJournal of Medicinal Chemistry, 1987
- Renin inhibitors. Design of angiotensinogen transition-state analogs containing novel (2R,3R,4R,5S)-5-amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic acidJournal of Medicinal Chemistry, 1987
- Design of peptide hormone and neurotransmitter analoguesTrends in Pharmacological Sciences, 1985
- Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statineJournal of Medicinal Chemistry, 1985
- Novel renin inhibitors containing the amino acid statineNature, 1983
- Enzymatic Catalysis and Transition-State TheoryScience, 1973
- PERMANGANATE–PERIODATE OXIDATION: VI. THE OXIDATION OF VARIOUS ALIPHATIC COMPOUNDSCanadian Journal of Chemistry, 1965