Effects of Erythropoietin and Androgens on Erythroid Stem Cells After Their Selective Suppression by BCNU

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Abstract
A single injection of BCNU (LD-10 range) caused in mice a prolonged suppression of erythropoiesis, whereas granulopoiesis recovered within a few days. The suppression of erythropoiesis was due to a delayed restoration of erythropoietin-responsive cells (ERC), although the CFU were only moderately suppressed and ranged from 30% to 60% of normal. Daily erythropoietin injections promptly restored normal ERC populations without affecting CFU. Injections of androgens after BCNU had no effect on ERC restoration, but they markedly enhanced CFU regeneration and caused neutrophil counts up to ten times normal.

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