Deregulated degradation of the cdk inhibitor p27 and malignant transformation
- 24 December 2002
- journal article
- review article
- Published by Elsevier in Seminars in Cancer Biology
- Vol. 13 (1) , 41-47
- https://doi.org/10.1016/s1044-579x(02)00098-6
Abstract
No abstract availableKeywords
This publication has 59 references indexed in Scilit:
- Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic LocalizationJournal of Biological Chemistry, 2002
- A Novel Target Gene, SKP2, within the 5p13 Amplicon That Is Frequently Detected in Small Cell Lung CancersThe American Journal of Pathology, 2002
- ErbB2/Neu-Induced, Cyclin D1-Dependent Transformation Is Accelerated in p27-Haploinsufficient Mammary Epithelial Cells but Impaired in p27-Null CellsMolecular and Cellular Biology, 2002
- A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phaseNature, 2001
- Role of the F-Box Protein Skp2 in Adhesion-Dependent Cell Cycle ProgressionThe Journal of cell biology, 2001
- Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplicationThe EMBO Journal, 2000
- p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27Current Biology, 1999
- Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cellsOncogene, 1998
- Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumoursOncogene, 1998
- Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-βScience, 1993