NEPHROTOXICITY OF CIS-DIAMMINEDICHLOROPLATINUM(II) AS MEASURED BY URINARY BETA-GLUCURONIDASE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 64  (10-1) , 1083-1086
Abstract
Urinary .beta.-glucuronidase activity as a measure of renal tubular damage was studied in 23 patients receiving 43 courses of cis-diamminedichloroplatinum(II) therapy [for cancer]. A 250% increase in urinary .beta.-glucuronidase activity was noted after therapy, compared with values before therapy. There were no patients who sustained renal insufficiency as evidenced by more commonly used and coarser parameters of renal function. This marked rise in urinary .beta.-glucuronidase activity was felt to indicate tubular toxicity due to the cis-diamminedichloroplatinum(II) not measured by the usual parameters of renal function.

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