THE EFFECTS OF INFUSING GLYCIN AND OF VARYING THE DIETARY PROTEIN INTAKE ON RENAL HEMODYNAMICS IN THE DOG

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Abstract
The intraven. adm. of glycin to the dog in amts. sufficient to raise the plasma conc. to 20 mg. % of amino nitrogen produces an increase in glomerular nitration rate and renal blood flow, and a decrease in nitration fraction and total renal resistance. The decrease in total renal resistance is largely localized in the efferent arterioles and postarteriolar vascular bed; the afferent arteriolar resistance changes but slightly. Glycin, in amts. sufficient to elevate the plasma conc to 60 mg. % amino nitrogen, is toxic and produces a decrease in glomerular filtration rate and renal blood flow, and an increase in fitration fraction and total renal resistance. The increase in total renal resistance results from an increase in each of the component renal resistances. An increase in the protein content of the maintenance diet increases blood flow and filtration rate, without altering filtration fraction significantly, and decreases total renal resistance. This decrease in total renal resistance is largely localized in vessels on the efferent side of the glomerulus.

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