Effects of Droperidol on Respiratory Drive in Humans
Open Access
- 1 August 1983
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 59 (2) , 113-116
- https://doi.org/10.1097/00000542-198308000-00008
Abstract
The sensitivity of the respiratory center following a single 0.3 mg .cntdot. kg-1 i.v. dose of droperidol [a hypnotic] was determined in 8 healthy volunteers by using CO2 rebreathing and mouth occlusion pressure measurements (P0.1). There were no significant differences in the mean slopes of the minute ventilation/partial pressure of CO2 (.ovrhdot.VE/PCO2) and log P0.1/PCO2 relationships between control measurements and those made 30, 60, 90, 150 and 240 min after droperidol administration. Individual variations in response were present, one subject showing significant (approximately 50%) depression of respiratory drive.Keywords
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