Reactiveness of Fetal Pituitary to Stressful Stimuli. Does the Maternal ACTH Cross the Placenta?

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Abstract
Stressful stimulus in intact fetuses, but not in decapitated fetuses, caused adrenal ascorbic acid depletion. ACTH injection into decapitated fetuses was followed by considerable adrenal ascorbic acid depletion. These data support the concept that the placenta is not permeable to ACTH.