ATTENUATED POLIOVIRUS INFECTION IN INFANTS FED COLOSTRUM FROM POLIOMYELITIS IMMUNE COWS
- 1 December 1963
- journal article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 32 (6) , 1039-1043
- https://doi.org/10.1542/peds.32.6.1039
Abstract
The ingestion of bovine colostrum, containing poliovirus neutralizing antibody, before the administration of 105.5 TCID50 of Sabin Type 2 vaccine prevented viral infection of the gastrointestinal tract in 8 of 11 3-day-old infants during a 16-day period of observation. The ingestion of colostrum after as short an interval as 2 hours following administration of the vaccine did not affect the incidence of infection, but it did appear either to delay the establishment of infection or to interfere temporarily with the isolation of virus from the feces. The ingestion of colostrum that did not possess poliovirus neutralizing antibody did not influence the incidence of infection.Keywords
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