Roles of Fibroblast Growth Factors in the Inner Ear
- 15 March 2002
- journal article
- Published by S. Karger AG in Audiology and Neurotology
- Vol. 7 (1) , 36-39
- https://doi.org/10.1159/000046861
Abstract
The basic biology of the fibroblast growth factor (FGF) receptors and their splice variants is first reviewed, followed by a review of the known roles of FGFs in the inner ear. They include induction of the otocyst by FGF19, followed by FGF3 in further development of the otocyst. In later development, FGF3 or FGF10 acting on FGF receptor 2b is likely to be involved in development of the walls of the cochlear spaces, while FGF receptor 3 is involved in differentiation of the pillar cells of the organ of Corti. FGF1 and FGF2 act as trophic factors for the developing cochlear nerve fibres.Keywords
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