Malakoplakia of the Kidney with Renal Failure

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Abstract
A case in which malakoplakia, a rare disease usually confined to the bladder mucosa, had destroyed most of the parenchyma of both kidneys, is reported. Acute suppurative pyelonephritis and papillary necrosis led to rapidly enlarging kidneys, uremia, and death. The pathognomonic Michaelis-Gutmann inclusion bodies, although sparse and difficult to identify by light microscopy, were readily demonstrable by electron microscopy in tissue fixed in 10% formalin. Electron microscopy, therefore, offers a means of establishing the diagnosis of malakoplakia when light microscopy is only suggestive. Special initial fixation procedures are not necessary.

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