Monoclonal antibodies block the bromelain‐mediated release of human placental alkaline phosphatase from cultured cancer cells
- 7 January 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 179 (2) , 316-320
- https://doi.org/10.1016/0014-5793(85)80542-1
Abstract
Certain monoclonal antibodies (mAbs) to human placental alkaline phosphatase (PLAP) block bromelain cleavage of a 2-kDa segment from each of the two polypeptide chains of PLAP. These mAbs also prevent the release of PLAP from cultured cancer cell surfaces by bromelain. Such proteolysis-blocking mAbs serve as tools to specifically modify the molecular topography of cell surfaces by protease treatment.Keywords
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