Helix-Coil Transitions in Specific Sequence Biopolymers
- 1 July 1975
- journal article
- research article
- Published by Taylor & Francis in International Journal of Polymeric Materials and Polymeric Biomaterials
- Vol. 4 (1-2) , 1-23
- https://doi.org/10.1080/00914037508072345
Abstract
The theory of helix-coil transitions in specific sequence biological macromolecules is reviewed. The importance of the cooperative nature of the transition (resulting in the tendency for long helical sequences to exist in the transition region) is stressed in that heterogeneity of polymer composition (hence heterogeneity of helix stability) tends to more or less localize long sequences of helix producing a pronounced profile of helical probability. The appropriate thermodynamic parameters and the resulting nature of the transitions for DNA, collagen, and proteins are compared. Some new calculations are given for carboxypeptidase A that includes heterogeneity in both the helix-coil parameters σ and s.Keywords
This publication has 26 references indexed in Scilit:
- Cooperative and thermodynamic parameters for oligoinosinate—polycytidylate complexesBiopolymers, 1973
- Evaluation of linear chain partition functions by computer derivation of secular equations. I. General technique; Titration of rigid macromoleculesThe Journal of Chemical Physics, 1973
- Helix-Coil Stability Constants for the Naturally Occurring Amino in Water. VII Phenylalanine Parameters from Random Poly(hydroxypropylglutamine-co-L-L-phenylalanine)Macromolecules, 1973
- Helix-Coil Stability Constants for the Naturally Occurring Amino Acids in Water. VI. Leucine Parameters from Random Poly(hydroxypropylglutamine-co-L-leucine) and Poly(hydroxybutylglutamine-co-L-leucine)Macromolecules, 1972
- Helix-Coil Stability Constants for the Naturally Occurring Amino Acids in Water. V. Serine Parameters from Random Poly(hydroxybutylglutamine-co-L-serine)Macromolecules, 1972
- A Model for the Helix-Coil Transition in Specific-Sequence Copolymers of Amino AcidsMacromolecules, 1971
- Effect of side-chain hydrophobic bonding on the stability of homopolyamino acid ?-helices: Conformational studies of poly-L-leucine in waterBiopolymers, 1970
- The Lifson‐Allegra theories of the helix–coil transition for random copolymers: Comparison with exact results and extensionBiopolymers, 1969
- Calculation of melting curves for DNABiopolymers, 1968
- A Conformation Examination of Poly-L-alanine and Poly-D,L-alanine in Aqueous SolutionJournal of the American Chemical Society, 1963