Comparative Studies on the Histo-Pathology of Syphilis, Yaws, and Pinta

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Abstract
Lesions of primary and secondary syphilis present pronounced inflammatory changes in the intima and media of the capillaries, whereas such changes are always absent in pinta and occur in yaws only in the late stages when sudden necrosis with ulceration sets in as a sensitization phenomenon. This "mesoder-motropism" or "panblastotropism" of Treponema pallidum and the "epidermotropism" of T. pertenue and T. pinta are correlated with the clinical manifestations of these 3 diseases, using as examples the early necrosis and ulceration of the primary lesion of syphilis and the occurrence of cardiovascular, central nervous system and congenital syphilis, and the absence of these manifestations in yaws and pinta.

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