Different response to inflammation of the multiple mRNAs of rat N‐acetylglucosaminyltransferase I with variable 5′‐untranslated sequences1
Open Access
- 2 October 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 436 (2) , 228-232
- https://doi.org/10.1016/s0014-5793(98)01136-3
Abstract
We found that there are at least five subclasses of N‐acetylglucosaminyltransferase I (GnT‐I; EC 2.4.1.101) mRNA with different 5′‐untranslated regions in rat brain. These five subclasses were also expressed in many tissues with distinct tissue‐specific patterns. Moreover, they were regulated differently in response to acute‐phase inflammation. The expression of the most abundant subclass of GnT‐I mRNA in rat liver decreased 2.5‐fold in response to inflammation, concomitantly with a significant decrease in the total amount of GnT‐I mRNA. In contrast, one of the minor subclasses of GnT‐I mRNA was induced 10‐fold by inflammation.Keywords
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