The effects of various immunosuppressive agents on antibody populations produced in guinea pigs.

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Abstract
Effects of immunosuppressive agents on immunochemical properties of antibody populations produced in guinea pigs were studied with methotrexate, cyclophosphamide, hydrocortisone, Bredinin (4-carbamoyl-1-.beta.-D-ribofuranosyl imidazolium-5-olate), azathioprine and 6-mercaptopurine. Methotrexate and cyclophosphamide alone suppressed strongly the antibody responses, not depending on the degree of the T [thymus derived] cell-dependency of antigens used. Hydrocortiscone, Bredinin and azathioprine also suppressed the antibody responses slightly and no effect was seen with 6-mercaptopurine. With cyclophosphamide and hydrocortisone no substantial difference in the susceptibility was seen between the IgG[immunoglobin G]1 and IgG2 antibody responses. The IgG1 antibody response appeared to be slightly more sensitive to the immunosuppressive activities of Bredinin and azathioprine compared with IgG2 antibody response. With methotrexate the difference in the susceptibility between these 2 responses seemed to vary depending on the kind of antigens used. The antigen-binding abilities of antibodies produced were not influenced by the treatment with methotrexate and cyclophosphamide.

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