Abstract
Acidified DMP (2,2-dimethoxypropane) was used as a combined dehydrating and clearing agent, permitting tissues to be led to paraffin less than an h after completed fixation. DMP reacts chemically with water, thereby insuring that the tissue becomes completely dehydrated. Histology and histochemistry of tissues after the DMP procedure was equal to that after conventional dehydration and clearing.

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