Unusual RNA and DNA binding properties of a novel pyrrolidine–amide oligonucleotide mimic (POM)
- 3 November 2000
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 22,p. 2251-2252
- https://doi.org/10.1039/b006903p
Abstract
A pentameric thymidyl pyrrolidine–amide oligonucleotide mimic (POM) was synthesised and shown to bind with very high affinity to complementary single stranded RNA and DNA, whilst exhibiting kinetic binding selectivity for RNA over DNA.Keywords
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