Plasma from Uninephrectomized Rats Increases 32P Incorporation into Phospholipids of Renal Cortical Slices

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Abstract
Incorporation of 32P into phospholipids of renal cortical slices was studied in vitro after addition of plasma from uninephrectomized or sham-operated rats. Plasma from uninephrectomized rats increased the labeling of phospholipids when obtained within the first hour after uninephrectomy. With different amounts of added plasma a graded response in labeling of phosphatidic acid and phosphatidylinositol was obtained. Phosphatidylcholine labeling also showed a graded response but only if the incubation time was prolonged. The results suggest that an early alteration in phospholipid metabolism, particularly of inositol lipids, may play a role in initiation of compensatory renal growth by humoral factor(s).