A Facile Synthesis of 1-Monosubstituted and Unsymmetrically 1,3-Disubstituted Uracils
- 1 January 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1990 (06) , 520-522
- https://doi.org/10.1055/s-1990-26926
Abstract
Heating of 2,4-bis(trimethylsiloxy)pyrimidine with functionalised alkyl halides in 1,2-dichloroethane in the presence of iodine affords exclusively 1-substituted uracils, which can be benzylated at N-3 with benzyl chloride under phase-transfer catalysis.Keywords
This publication has 0 references indexed in Scilit: