Undetected Chromosome Abnormalities in Leukemia: A Cautionary Note
- 30 April 1981
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 304 (18) , 1109-1110
- https://doi.org/10.1056/nejm198104303041818
Abstract
To the Editor: We and others have demonstrated that in patients in whom acute nonlymphocytic leukemia develops after cytotoxic therapy for a primary neoplasm (often malignant lymphoma), an aneuploid clone is frequently present in their leukemic cells.1 2 3 Most commonly, the abnormality is a loss of part or all of Chromosomes 5 or 7 or both.1 , 2 Of 33 patients with secondary leukemia whose chromosomes we analyzed, only three appeared to have a normal karyotype in the first sample that we received; two of these patients were in the leukemic phase and the third was in the preleukemic phase. Our findings in . . .Keywords
This publication has 4 references indexed in Scilit:
- Abolished Production of Interferon by Leucocytcs of Patients with the Acquired Cytogcnetic Abnormalities 5q — or — 5 in Secondary and de‐Novo Acute Non‐lymphocytic LeukaemiaBritish Journal of Haematology, 1980
- Chromosome abnormalities in cancerCancer Genetics and Cytogenetics, 1980
- Chromosomes in Acute Non‐lymphocytic LeukaemiaBritish Journal of Haematology, 1978
- 15/17 TRANSLOCATION, A CONSISTENT CHROMOSOMAL CHANGE IN ACUTE PROMYELOCYTIC LEUKAEMIAThe Lancet, 1977