Oxytetracycline Absorption and Excretion in Wethers

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Abstract
Three trials were conducted to evaluate the absorption and excretion of oxytetracycline (OTC) in wethers. In trial 1, six wethers were given 1 g of OTC per day for 14 days orally or abomasally (via abomasal fistula) and were fed either a high or low fiber diet. OTC was detected in serum 1 and 4 hr post-dosing in abomasally and orally dosed wethers, respectively. Abomasally dosed wethers had higher (P<.01) OTC levels in serum collected serially on the first day of dosing. Wethers dosed abomasally and (or) fed a low fiber diet had higher (P<.01) OTC levels in serum collected on day 14. In the second trial, four wethers were dosed orally (via rumen fistula) and abomasally for 14 days with 1.0 g of OTC per day. The same design was used in the third trial, but 100 mg of OTC were administered per day. Route of administration in trial 2 had an effect (P<.01) on OTC levels in serum collected serially on the first day of dosing, as seen in trial 1. In trial 2, wethers dosed abomasally had higher mean fecal OTC recovery (P<.05) and 14-day serum levels (P<.01). Serum OTC levels in trial 3 were below the detectable level. While route of administration in trial 3 produced no detectable effect (P>.05) on recovery of OTC in the feces, abomasally dosed animals had higher values as was observed in trial 2. Copyright © 1979. American Society of Animal Science . Copyright 1979 by American Society of Animal Science.