Synthesis of di‐amino‐salicil and some of its derivatives
- 1 January 1955
- journal article
- research article
- Published by Wiley in Recueil des Travaux Chimiques des Pays-Bas
- Vol. 74 (11) , 1323-1342
- https://doi.org/10.1002/recl.19550741103
Abstract
From the work of R. Kuhn et al. it appeared that brominated derivatives of salicil have a high anti‐bacterial activity in vitro, but that in vivo they show only little activity as a result of serum‐binding. Base‐substituted phenols are usually bound by serum to a smaller extent. Therefore, an amino‐substituted bromo‐salicil was synthesized. A water soluble derivative of this compound was also prepared.Keywords
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