Body size and testicular cancer.

Abstract
The incidence of testicular cancer has been increasing markedly among many populations worldwide for as long as cancer occurrence has been assessed (1,2). The cause of this increase, however, remains unknown. Sex hormones are instrumental in the growth and in the development of the testicle, both prenatally and postnatally, and have, therefore, frequently been the focus of etiologic research. Obesity often reflects increased levels of estradiol and estrone (3). We have performed a study of a cohort of approximately 500 000 Norwegian men to investigate the relation between body size, measured by height and body mass index (BMI), and testicular cancer.

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