STRUCTURE‐ACTIVITY RELATIONSHIPS AMONG THE HALOGENATED AMPHETAMINES
- 1 June 1978
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 305 (1) , 147-159
- https://doi.org/10.1111/j.1749-6632.1978.tb31518.x
Abstract
P-Chloroamphetamine and various analogs influence brain serotonin neurons through multiple actions. Comparison of these compounds has permitted the distinction between short-term and long-term depletion of serotonin and among inhibition of tryptophan hydroxylation, release of serotonin, inhibition of serotonin reuptake, and inhibition of monoamine oxidase as mechanisms involved in the actions of these agents on serotonin neurons.Keywords
This publication has 36 references indexed in Scilit:
- Behavioral evidence for the rapid release of CNS serotonin by PCA and fenfluramineEuropean Journal of Pharmacology, 1976
- Kinetics of serotonin accumulation into synaptosomes of rat brain-effects of amphetamine and chloroamphetaminesBiochemical Pharmacology, 1973
- p-Chloroamphetamine—inhibition of cerebral tryptophan hydroxylaseBiochemical Pharmacology, 1972
- Structural specificity for inhibition of [14C]-5-hydroxytryptamine uptake by cerebral slicesJournal of Pharmacy and Pharmacology, 1970
- Serotonin oxidation by rat brain monoamine oxidase: Inhibition by 4-chloroamphetamineLife Sciences, 1966
- Two types of monoamine liberation by chlorinated aralkylaminesLife Sciences, 1965
- Lowering of brain serotonin level by chloramphetaminesBiochemical Pharmacology, 1965
- Decrease of cerebral 5-hydroxytryptamine and 5-hydroxyindolacetic acid by an arylalkylamineLife Sciences, 1963
- Psychopharmacological Studies of Some 1-(Chlorophenyl)-2-aminopropanes IJournal of Pharmaceutical Sciences, 1963
- Psychopharmacological Studies of Some 1- (Chlorophenyl) -2-aminopropanes IIJournal of Pharmaceutical Sciences, 1963