Localization of the human myelin basic protein gene (MBP) to region 18q22→qter by in situ hybridization
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 39 (4) , 246-249
- https://doi.org/10.1159/000132152
Abstract
A restriction endonuclease fragment derived from a cloned portion of human genomic DNA corresponding to the myelin basic protein gene has been used to map the position of this gene by in situ hybridization to human metaphase chromosomes. Ten percent of the radioactively labeled sites observed were on chromosome 18. Eighty-four percent of the grains on chromosome 18 were located within the region corresponding to 18q22→qter. This represents a greater than 10-fold increase in labeling at this position over the background grain distribution found along all of the other chromosomes.Keywords
This publication has 11 references indexed in Scilit:
- Characterization of cloned cDNA representing rat myelin basic protein: Absence of expression in brain of shiverer mutant miceCell, 1983
- Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive Chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: Assignment of humanasnS gene to chromosome 18Somatic Cell and Molecular Genetics, 1983
- Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridizationChromosoma, 1981
- CONFIRMATION OF THE REGIONAL ASSIGNMENT OF PEPTIDASE A (PEPA) TO 18Q23 BY GENE DOSAGE STUDIES1980
- QUAKING MOUSE MYELIN: BIOCHEMICAL CHARACTERIZATION OF ZONAL GRADIENT SUBFRACTIONSJournal of Neurochemistry, 1979
- Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelinNeuroscience Letters, 1979
- The ovalbumin gene: Alleles created by mutations in the intervening sequences of the natural geneCell, 1979
- Assignment of the gene for dipeptidase 2 to Mus musculus chromosome 18 by somatic cell hybridizationBiochemical Genetics, 1978
- The gene for human peptidase A is on band 18q23 and shows triplex and uniplex dosage effectHuman Genetics, 1978
- Gene mapping in Mus musculusby interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2Cytogenetic and Genome Research, 1977