Strategies for Targeting Protein–Protein Interactions With Synthetic Agents
Top Cited Papers
- 23 June 2005
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 44 (27) , 4130-4163
- https://doi.org/10.1002/anie.200461786
Abstract
The development of small‐molecule modulators of protein–protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low‐molecular‐weight ligands. This review discusses the strategies for targeting protein–protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.Keywords
This publication has 355 references indexed in Scilit:
- Terphenyl‐Based Helical Mimetics That Disrupt the p53/HDM2 InteractionAngewandte Chemie International Edition in English, 2005
- In silico identification of functional protein interfacesComparative and Functional Genomics, 2003
- A Salt Bridge between an N-terminal Coiled Coil of gp41 and an Antiviral Agent Targeted to the gp41 Core Is Important for Anti-HIV-1 ActivityBiochemical and Biophysical Research Communications, 2000
- Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. CohenJournal of Molecular Biology, 1999
- PDGF-BB increases endothelial migration and cord movements during angiogenesis in vitroJournal of Cellular Biochemistry, 1997
- Adhesion Molecules as Targets for the Treatment of Autoimmune DiseasesClinical Immunology and Immunopathology, 1996
- Coupling Protein Design andin VitroSelection Strategies: Improving Specificity and Affinity of a Designed β-protein IL-6 AntagonistJournal of Molecular Biology, 1996
- The Trk family of neurotrophin receptorsJournal of Neurobiology, 1994
- p75 nerve growth factor receptor modulates p140trkA kinase activity, but not ligand internalization, in PC12 cellsJournal of Neuroscience Research, 1994
- Comparison of a Structural and a Functional EpitopeJournal of Molecular Biology, 1993