Cyclosporin A-treated guinea pig responder cells secrete a genetically restricted factor that suppresses the mixed leukocyte reaction.
Open Access
- 1 January 1983
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 71 (1) , 165-169
- https://doi.org/10.1172/jci110746
Abstract
Cyclosporin A (CY A) is a hydrophobic, undecapeptide, fungal metabolite with potent immunosuppressive effects on T lymphocyte-mediated immune responses. Suppressor T lymphocytes generated during a mixed leukocyte reaction (MLR) performed in the presence of CY A, release a factor that suppresses a primary MLR of responder T cells, which is derived from the same strain as the factor producer but lacks specificity for the stimulator cell. These results suggest a finely regulated pathway by which CY A may induce and maintain a permanent state of transplantation tolerance in vivo.This publication has 14 references indexed in Scilit:
- Effect of cyclosporin A on T cell function in vitro: the mechanism of suppression of T cell proliferation depends on the nature of the T cell stimulus as well as the differentiation state of the responding T cell.The Journal of Immunology, 1982
- CYCLOSPORIN A SPARES SELECTIVELY LYMPHOCYTES WITH DONOR-SPECIFIC SUPPRESSOR CHARACTERISTICSTransplantation, 1981
- Effect of cyclosporin A on human lymphocyte responses in vitro. II. Induction of specific alloantigen unresponsiveness mediated by a nylon wool adherent suppressor cell.The Journal of Immunology, 1981
- Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2European Journal of Immunology, 1981
- Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.The Journal of Immunology, 1980
- Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.The Journal of Immunology, 1980
- Immunosuppression for Organ Grafting Observations on Cyclosporin AImmunological Reviews, 1979
- Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.The Journal of Experimental Medicine, 1979
- EFFECTS OF NEW ANTI-LYMPHOCYTIC PEPTIDE CYCLOSPORIN-A IN ANIMALS1977
- Regulatory mechanisms in cell-mediated immune responses. IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphocytes.The Journal of Experimental Medicine, 1976