GENERAL EDEMA OF INDETERMINATE ETIOLOGY

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Abstract
Occasionally we observe patients with edema who do not present clinical evidence of the pathologic conditions that usually produce edema. They do not have nephritis, for the conditions ordinarily observed in nephritis are not present. Nor do they have hypertension, myocardial degeneration with congestive failure, cirrhosis, polyserositis, myxedema or a malignant growth. The patients are usually well nourished and have been accustomed to a well balanced diet. No evidence of infection or toxemia is found, but there is a history of gradual progressive edema over a period of months that does not respond to the usual therapeutic measures. Except for the edema the patient feels quite well and on first impression one would make a diagnosis of lipoid nephrosis. On study, however, we find that there is no albumin in the urine; yet the value for serum protein is low, less than 5 Gm. per hundred cubic centimeters, and the

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