Pyripyropenes, Novel ACAT Inhibitors Produced by Aspergillus fumigatus. III. Structure Elucidation of Pyripyropenes E to L.
- 1 January 1995
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 48 (6) , 495-503
- https://doi.org/10.7164/antibiotics.48.495
Abstract
Eight new pyripyropenes, E to L, were isolated from the culture broth of Aspergillus fumigatus FO-1289-2501 selected as a higher producer by NTG mutation. Structural elucidation indicated that all the pyripyropenes have the same pyridino-alpha-pyrone sesquiterpene core as pyripyropenes A to D. Among them, pyripyropene L showed the most potent inhibition against acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 value of 0.27 microM in rat liver microsomes.Keywords
This publication has 0 references indexed in Scilit: